Concepedia

PD-1 Is Expressed by Tumor-Infiltrating Immune Cells and Is Associated with Poor Outcome for Patients with Renal Cell Carcinoma

R. Houston Thompson, Haidong Dong, Christine M. Lohse, Bradley C. Leibovich, Michael L. Blute, John C. Cheville, Eugene D. Kwon

Clinical Cancer Research · 2007 · 559 citations · 17 references

DOI

Abstract

Levels of immune cells expressing PD-1 were increased in patients with high-risk RCC tumors. Interactions between immune cell PD-1 and B7-H1 may promote cancer progression by contributing to immune dysfunction in patients with RCC.

References

17

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Yasumasa Ishida, Yasutoshi Agata, Kei‐ichi Shibahara et al. · The EMBO Journal · 1992 · 3.1K citations · Full text

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Cheryl L. Day, Daniel E. Kaufmann, Photini Kiepiela et al. · Nature · 2006 · 2.6K citations

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Lydie Trautmann, Loury Janbazian, Nicolas Chomont et al. · Nature Medicine · 2006 · 1.5K citations

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An Outcome Prediction Model for Patients with Clear Cell Renal Cell Carcinoma Treated with Radical Nephrectomy Based on Tumor Stage, Size, Grade and Necrosis: The Ssign Score

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