Concepedia

Mechanistic Investigation of the Preclinical Pharmacokinetics and Interspecies Scaling of PF-05231023, a Fibroblast Growth Factor 21–Antibody Protein Conjugate

Craig Giragossian, Chandra Vage, Jun Li, Kathleen Pelletier, Nicole Piche‐Nicholas, Manoj Rajadhyaksha, Jennifer L. Liras, Alison Logan, Roberto A. Calle, Yan Weng

Drug Metabolism and Disposition · 2015 · 20 citations · 35 references

DOI

Concepts

References

35

The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes

Gregory Gaich, Jenny Y. Chien, Haoda Fu et al. · Cell Metabolism · 2013 · 879 citations · Full text

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Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo.

Carolyn F. Deacon, Anders H. Johnsen, Jens J. Holst · The Journal of Clinical Endocrinology & Metabolism · 1995 · 757 citations

, , +16

The Metabolic State of Diabetic Monkeys Is Regulated by Fibroblast Growth Factor-21

Alexei Kharitonenkov, Victor J. Wroblewski, Anja Köester et al. · Endocrinology · 2006 · 734 citations

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Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

Dhaval K. Shah, Alison Betts · Journal of Pharmacokinetics and Pharmacodynamics · 2011 · 417 citations

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Physiologically-based pharmacokinetic (PBPK) model to predict IgG tissue kinetics in wild-type and FcRn-knockout mice

Amit Garg, Joseph P. Balthasar · Journal of Pharmacokinetics and Pharmacodynamics · 2007 · 322 citations

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