Arsenic trioxide induces not only apoptosis but also autophagic cell death in leukemia cell lines via up-regulation of Beclin-1

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Xiao Huan Liang, Saadiya Jackson, Matthew Seaman et al. · Nature · 1999 · 3.3K citations

Life Sciences, Cancer Biology, Cell Biology +12

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

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Life Sciences, Genetics, Oncology +15

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

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Life Sciences, Cell Biology, Oncology +17

Use of Arsenic Trioxide (As2O3 ) in the Treatment of Acute Promyelocytic Leukemia (APL): II. Clinical Efficacy and Pharmacokinetics in Relapsed Patients

Zhixiang Shen, Guoqiang Chen, Jian-Hua Ni et al. · Blood · 1997 · 1.4K citations

Medicine, Pharmacokinetics, Pharmacology +17

Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes

Shigeomi Shimizu, Toku Kanaseki, Noboru Mizushima et al. · Nature Cell Biology · 2004 · 1.3K citations

Life Sciences, Cell Biology, Molecular Biology +16