Concepedia

7-Nitroindazole Inhibits Brain Nitric Oxide Synthase and Cerebral Vasodilatation in Response to <i>N</i> -Methyl- <scp>d</scp> -aspartate

Frank M. Faraci, Johnny E. Brian

Stroke · 1995 · 91 citations · 28 references

DOI

Abstract

These findings suggest that vasodilatation in response to NMDA is mediated by neuronally derived NO. 7-NI appears to produce selective inhibition of brain NO synthase but not endothelial NO synthase.

References

28

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Paul L. Huang, Ted M. Dawson, David S. Bredt et al. · Cell · 1993 · 1.3K citations

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Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction.

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Characterization of the novel nitric oxide synthase inhibitor 7‐nitro indazole and related indazoles: antinociceptive and cardiovascular effects

Philip K. Moore, P Wallace, Z. Gaffen et al. · British Journal of Pharmacology · 1993 · 464 citations · Full text

7‐Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti‐nociceptive activity in the mouse without increasing blood pressure

Peter K. Moore, R.C. Babbedge, P Wallace et al. · British Journal of Pharmacology · 1993 · 423 citations · Full text