Efficacy and Safety of Adefovir Dipivoxil With Antiretroviral Therapy<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

Abstract

This study suggests that once-daily adefovir therapy reduces HIV RNA and is active against isolates resistant to lamivudine or lamivudine and zidovudine. Nephrotoxicity occurred when treatment extended beyond 24 weeks but was reversible.