Nonpeptidic Vinyl and Allyl Phosphonates as Falcipain‐2 Inhibitors

Abstract

Antimalarials: The aim of our work was to investigate the ability of nonpeptidic vinyl and allyl phosphonates to inhibit falcipain-2 (FP-2), the main cysteine protease of P. falciparum. Some of the compounds synthesized, such as the one shown, moderately inhibit FP-2 activity.