A General Sultone Route to the Pamamycin Macrodiolides—Total Synthesis of Pamamycin‐621A and Pamamycin‐635B

Abstract

Sultones swing again: The first total syntheses of the title antibiotics (see scheme) were achieved by application of sultone methodology. Since the final lactonizations with formation of the ester linkage between C1′ and the oxygen substituent on C8 proceeded with complete epimerization at C2′, the more readily available C2′ epimeric smaller fragments could be used for streamlining the synthetic sequence.