Increased utility in the CNS of a powerful neuron‐specific tetracycline‐regulatable adenoviral system developed using a post‐transcriptional enhancer

Abstract

We have further developed a tetracycline-regulatable neuron-specific expression system such that it can now be used at low titres with no loss of transgene expression or ability to regulate transgene expression. It should therefore be of significant value to studies investigating neuronal gene function and to those seeking to develop effective neuronal gene therapy strategies.