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Solution conformation of methylated macrolide antibiotics roxithromycin and erythromycin using NMR and molecular modelling. Ribosome-bound conformation determined by TRNOE and formation of cytochrome P450-metabolite complex

Cytochrome P450-metabolite ComplexBiochemistrySolution ConformationNatural SciencesRational Drug DesignMolecular BiologyConformational StudyStructure-function Enzyme KineticsAntimicrobial ChemotherapySolution Nmr SpectroscopyMedicineMolecular ModelingRibosome-bound ConformationStructural BiologyDrug Discovery