Mir-148A Plays A Pivotal Role in the Liver by Promoting the Hepatospecific Phenotype And Suppressing the Invasiveness of Transformed Cells

Abstract

miR-148a is essential for the physiology of the liver because it promotes the hepatospecific phenotype and acts as a tumor suppressor. Most important, this report is the first to demonstrate a functional role for a specific miRNA in liver development through regulation of the DNMT1 enzyme.