Efficient Delivery of Bioactive Antibodies into the Cytoplasm of Living Cells by Charge‐Conversional Polyion Complex Micelles

Abstract

Stand and deliver! Immunoglobulin G (IgG) can be delivered into the cytoplasm of living cells by charge-conversional modification followed by treatment with a cationic block copolymer to form polyion complex (PIC) micelles (see picture). The bioactivity of the IgG selectively recovers in the cell in a pH-dependent manner, thereby controlling the growth of human hepatoma cells through IgG binding to intracellular target molecules. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.