2-Benzimidazolyl-9-(chroman-4-yl)-purinone derivatives as JAK3 inhibitors

Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

Paolo Macchi, Anna Villa, Silvia Giliani et al. · Nature · 1995 · 885 citations

Life Sciences, Genetics, Molecular Genetics +13

Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development

Sarah M. Russell, Nahid Tayebi, Hiroshi Nakajima et al. · Science · 1995 · 814 citations · Full text

Life Sciences, Genetics, Immunology +17

Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor

Paul S. Changelian, Mark E. Flanagan, Douglas J. Ball et al. · Science · 2003 · 670 citations · Full text

Medicine, Immunology, Pharmacology +17

Photochemical preparation of a pyridone containing tetracycle: A jak protein kinase inhibitor

James E. Thompson, Rose M. Cubbon, Richard Cummings et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 270 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Phase 1 Dose-Escalation Study of CP-690 550 in Stable Renal Allograft Recipients: Preliminary Findings of Safety, Tolerability, Effects on Lymphocyte Subsets and Pharmacokinetics

Eveline van Gurp, Willem Weimar, Robert S. Gaston et al. · American Journal of Transplantation · 2008 · 73 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +14