Publication | Closed Access
Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles
75
Citations
26
References
2008
Year
Crystal StructureNucleic Acid ChemistryDnaEngineeringGeneticsIncreased Rna AffinityDna AnalysisOligonucleotideMolecular BiologyDna ReplicationStructure ElucidationMolecular GeneticsSuperior ResistanceUnusual Compensatory ChangeMedicineCrystallographyStructural BiologyBiomolecular Engineering
The crystal structure of a DNA duplex with tricyclo-DNA (tc-DNA) residues explains the increased RNA affinity of tc-DNA relative to DNA and tc-DNA's superior resistance to nucleases.
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