Antithrombogenic Poly(vinyl chloride) with Heparin- and/or Prostaglandin I2-Immobilized in Hydrogels

Abstract

Poly(vinyl chloride) (PVC) with heparin- and/or prostaglandin I 2 (PGI 2 )- immobilized on crosslinked polyacrylamide hydrogels were prepared by the ad dition of the dry hydrogels to a PVC tetrahydrofuran solution. Immobilized heparin was found to be continuously released from the PVC matrix at 37 ° C in a physiological saline. Antithrombogenic activity of PVCs with heparin and/or PGI 2 was evaluated by activated partial thromboplastin time (aPTT), whole blood clotting time, and inhibition of platelet aggregation. The heparin- immobilized PVC's exhibited excellent anticoagulant activity and the PGI 2 immobilized PVC's completely inhibit platelet aggregation of human blood after sitting for 46 h in a physiological saline.