Effect of Several 5-Hydroxytryptamine1A Receptor Ligands on the Micturition Reflex in Rats: Comparison with WAY 100635

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

André DeLÉAN, Peter J. Munson, David Rodbard · American Journal of Physiology-Endocrinology and Metabolism · 1978 · 2.4K citations

Medicine, Biostatistics, Pharmacology +17

The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-Propylamino) tetralin in the rat

Mark D. Tricklebank, Christian Forler, John R. Fozard · European Journal of Pharmacology · 1984 · 677 citations

Medicine, Neuroscience, Pharmacology +16

Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist

Allan Fletcher, Elaine A. Forster, David J. Bill et al. · Behavioural Brain Research · 1995 · 521 citations

Medicine, Neuroscience, Pharmacology +13

Origins of serotonergic projections to the spinal cord in rat: An immunocytochemical-retrograde transport study

Robert M. Bowker, Karin N. Westlund, J.D. Coulter · Brain Research · 1981 · 316 citations

Life Sciences, Neurobiology, Neuroscience +16