Characterizing and predicting the functional and conformational diversity of seven-transmembrane proteins

Amino acid substitution matrices from protein blocks.

Steven Henikoff, Jorja G. Henikoff · Proceedings of the National Academy of Sciences · 1992 · 6.4K citations

Life Sciences, Bioinformatics, Evolutionary Biology +16

Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

Krzysztof Palczewski, Takashi Kumasaka, Tetsuya Hori et al. · Science · 2000 · 5.6K citations

Life Sciences, Biochemistry, Biophysics +16

High-Resolution Crystal Structure of an Engineered Human β ₂ -Adrenergic G Protein–Coupled Receptor

Vadim Cherezov, Daniel M. Rosenbaum, Michael A. Hanson et al. · Science · 2007 · 3.3K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Crystal structure of the β2 adrenergic receptor–Gs protein complex

Søren G. F. Rasmussen, Brian T. DeVree, Yaozhong Zou et al. · Nature · 2011 · 3.1K citations · Full text

Life Sciences, Biochemistry, Pharmacology +12

The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints

Robert Fredriksson, Malin C. Lagerström, Lars‐Gustav Lundin et al. · Molecular Pharmacology · 2003 · 2.9K citations

Life Sciences, Genetics, Molecular Biology +13