Real‐Time Monitoring of Organic Reactions with Two‐Dimensional Ultrafast TOCSY NMR Spectroscopy

Abstract

A quick look reveals all: A two-dimensional ultrafast TOCSY experiment in one scan is presented and used to study the synthesis of pyrimidine from an aliphatic ketone, a nitrile, and Tf2O. 525 two-dimensional TOCSY experiments were recorded, and the reactants, intermediates, and products could be monitored (see picture; blue=product; gray, green, and pink=intermediates). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.