Nonopioidergic Mechanism Mediating Morphine-Induced Antianalgesia in the Mouse Spinal Cord

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

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Intrathecal morphine in mice: A new technique

Janice L.K. Hylden, George L. Wilcox · European Journal of Pharmacology · 1980 · 1.9K citations

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Hyperalgesia Mediated by Spinal Glutamate or Substance P Receptor Blocked by Spinal Cyclooxygenase Inhibition

Annika B. Malmberg, Tony L. Yaksh · Science · 1992 · 720 citations

Medicine, Pharmacology, Pharmacotherapy +17

Single intrathecal injections of dynorphin A or des-Tyr-dynorphins produce long-lasting allodynia in rats: blockade by MK-801 but not naloxone

Todd W Vandera, Tinna M. Laughlin, Jason Lashbrook et al. · Pain · 1996 · 222 citations

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Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons, thereby increasing its antinociceptive potency and attenuating tolerance/dependence during chronic cotreatment.

Stanley M. Crain, Kai Shen · Proceedings of the National Academy of Sciences · 1995 · 204 citations

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