JunB promotes cell invasion and angiogenesis in VHL-defective renal cell carcinoma

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Patrick H. Maxwell, Michael S. Wiesener, Gin-Wen Chang et al. · Nature · 1999 · 5.2K citations

Tumor Biology, Hypoxia-inducible Factors, Oxygen-dependent Proteolysis +9

Intratumor microvessel density as a prognostic factor in cancer.

Noel Weidner · PubMed Central · 1995 · 876 citations · Full text

Medicine, Biological Microenvironments, Intratumor Microvessel Density +6

Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression

Rosalba Salcedo, M. Lourdes Ponce, Howard A. Young et al. · Blood · 2000 · 820 citations

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

Keiichi Kondo, Jeff Klco, Eijiro Nakamura et al. · Cancer Cell · 2002 · 766 citations · Full text

Tumor Biology, Von Hippel-lindau Protein, Tumor Suppression +10

Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors

Sunyoung Lee, Shahla M. Jilani, Ganka Nikolova et al. · The Journal of Cell Biology · 2005 · 690 citations · Full text

Tumor Biology, Angiogenesis, Mmp Processing +18