Concepedia

Loss of Stearoyl-CoA Desaturase-1 Attenuates Adipocyte Inflammation

Xueqing Liu, Makoto Miyazaki, Matthew T. Flowers, Harini Sampath, Minghui Zhao, Kiki Chu, Chad M. Paton, Diane Seohee Joo, James M. Ntambi

Arteriosclerosis Thrombosis and Vascular Biology · 2009 · 84 citations · 26 references

DOIFull text

Open access

Abstract

Loss of SCD1 attenuates adipocyte inflammation and its paracrine regulation of inflammation in macrophages and endothelial cells. The reduced oleate level is linked to the inflammation-modulating effects of SCD1 deficiency.

References

26

Obesity is associated with macrophage accumulation in adipose tissue

Stuart P. Weisberg, Daniel McCann, Manisha Desai et al. · Journal of Clinical Investigation · 2003 · 8.6K citations · Full text

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Obesity is associated with macrophage accumulation in adipose tissue

Stuart P. Weisberg, Daniel McCann, Manisha Desai et al. · Journal of Clinical Investigation · 2003 · 8.2K citations · Full text

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Gökhan S. Hotamışlıgil, Narinder S. Shargill, Bruce M. Spiegelman · Science · 1993 · 7.4K citations

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Haiyan Xu, Glenn T. Barnes, Qing Yang et al. · Journal of Clinical Investigation · 2003 · 5.8K citations · Full text

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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Haiyan Xu, Glenn T. Barnes, Qing Yang et al. · Journal of Clinical Investigation · 2003 · 5.6K citations

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