Publication | Closed Access
Label‐Free Imaging of Metal–Carbonyl Complexes in Live Cells by Raman Microspectroscopy
171
Citations
21
References
2010
Year
EngineeringMicroscopySurface-enhanced Raman ScatteringMolecular BiologyRaman MicrospectroscopyLight Scattering SpectroscopySpectra-structure CorrelationRaman Intensity ImagesMolecular ImagingBiophysicsNovel Imaging MethodMolecular SciencesLabel‐free ImagingNew KidCo VibrationSolution Nmr SpectroscopyBiomolecular ScienceSingle-molecule DetectionBiomolecular EngineeringSpectroscopyBiomedical ImagingMetal–carbonyl ComplexesMolecular BiophysicsMedicineSpectroscopic Method
A new kid in town: 3D Raman intensity images of a HT29 colon cancer cell incubated with an aqueous solution of the CO-releasing metal–carbonyl complex 1 show that the compound penetrates the cellular membrane and is localized mainly in the nuclear membrane and the nucleolus. The CO vibration of 1 serves as an intrinsic spectroscopic label.
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