Angewandte Chemie International Edition · 2009 · 59 citations · 18 references
PharmacyBiochemistryPharmaceutical AnalysisBiopharmaceuticsProtein BiochemistrySpectroscopyMagnetic Resonance SpectroscopyPeptide AnalysisPeptide ChemistryProtein ChemistryProtein StructureSpectroscopic Analysis Of PharmaceuticalsIsotopic Labeling Of PeptidesMagnetic Resonance Spectroscopy Of BiomoleculesMultidimensional Nmr SpectroscopyPeptide Medicinal ChemistryPeptide Structure Analysis
The natural way: A sensitive NMR spectroscopic method is developed to obtain well-resolved two-dimensional spectra ((15)N-(1)H and (13)C-(1)H) for natural-abundance (that is, without the need for isotopic enrichment) large-molecule samples, such as biopharmaceuticals. This method gives structural insights on two lyophilized aprotinin samples and three insulin samples in lyophilized, microcrystalline suspension formulation (red; see picture) and fibril (green) forms.
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Structure of a protein determined by solid-state magic-angle-spinning NMR spectroscopy
Federica Castellani, Barth‐Jan van Rossum, Anne Diehl et al. · Nature · 2002 · 907 citations
Correlation of structural elements and infectivity of the HET-s prion
Christiane Ritter, Marie‐Lise Maddelein, Ansgar B. Siemer et al. · Nature · 2005 · 438 citations · Full text