Circadian Integration of Glutamatergic Signals by Little SAAS in Novel Suprachiasmatic Circuits

Abstract

Little SAAS relays signals downstream of light/glutamatergic signaling from eye to SCN, and independent of VIP and GRP action. These findings suggest that little SAAS forms a third SCN neuropeptidergic system, processing light information and activating phase-shifts within novel circuits of the central circadian clock.