Concepedia

Kinetic resolution of aromatic β-amino acids by ω-transaminase

Han‐Seop Bea, Hye‐Jeong Park, Sang‐Hyeup Lee, Hyungdon Yun

Chemical Communications · 2011 · 63 citations · 30 references

DOI

Concepts

Abstract

Racemic aromatic β-amino acids have been kinetically resolved into (R)-β-amino acids with high enantiomeric excess (>99%) by a novel ω-TA with ca. 50% conversion.

References

30

Quantitative analyses of biochemical kinetic resolutions of enantiomers

Ching Shih Chen, Yoshitaka Fujimoto, Gary Girdaukas et al. · Journal of the American Chemical Society · 1982 · 2.6K citations

, , +9

Recent advances in the stereoselective synthesis of β-amino acids

Mei Liu, Mukund P. Sibi · Tetrahedron · 2002 · 641 citations

, , +15

Biocatalytic Routes to Optically Active Amines

Matthias Höhne, Uwe T. Bornscheuer · ChemCatChem · 2009 · 383 citations

, , +17

Formal Asymmetric Biocatalytic Reductive Amination

Dominik Koszelewski, Iván Lavandera, Dorina Clay et al. · Angewandte Chemie International Edition · 2008 · 239 citations

, , +10

Biocatalysis as a profound tool in the preparation of highly enantiopure β-amino acids

Arto Liljeblad, Liisa T. Kanerva · Tetrahedron · 2006 · 225 citations

, , +14