Synthetic Access to the Chlorocyclopentane Cores of the Proposed Original and Revised Structures of Palau′amine

Abstract

Core knowledge: The synthesis of the functionalized cores of both the originally proposed and revised structures of palau′amine have been achieved (see structures). A Diels–Alder/[3,3]-sigmatropic rearrangement sequence and a Beckmann rearrangement enable the stereocontrolled formation of the highly congested cores.