Green Chemistry · 2012 · 49 citations · 6 references
Solvent ExtractionEngineeringOrganic ChemistryChemistryChemical EngineeringMedicinal ChemistrySeparation ScienceGas ChromatographyAlternative SolventsAnalytical ChemistryLiquid ChromatographyClinical ChemistryPurification MethodAdvanced SeparationChromatographyChromatographic AnalysisPharmacologyBulk MediaChromatographic PurificationMedicineBulk MediumDrug Analysis
Replacement of dichloromethane as the bulk medium within chromatographic purification has been evaluated with a broad range of molecules containing functionality common within Medicinal Chemistry programmes. Analysis of the data set has generated a set of general guidelines to assist in the selection of alternative solvents for CH2Cl2 as the bulk media in these ubiquitously employed processes.
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Richard K. Henderson, Concepción Jiménez‐González, David J. C. Constable et al. · Green Chemistry · 2011 · 1.1K citations
Pharmaceutical Science, Pharmaceutical Research, Engineering +23