Targeting hyaluronic acid production for the treatment of leukemia: Treatment with 4-methylumbelliferone leads to induction of MAPK-mediated apoptosis in K562 leukemia

Three Isoforms of Mammalian Hyaluronan Synthases Have Distinct Enzymatic Properties

Naoki Itano, Takahiro Sawai, Mamoru Yoshida et al. · Journal of Biological Chemistry · 1999 · 898 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +11

Hyaluronan-CD44 Interaction with Protein Kinase Cϵ Promotes Oncogenic Signaling by the Stem Cell Marker Nanog and the Production of MicroRNA-21, Leading to Down-regulation of the Tumor Suppressor Protein PDCD4, Anti-apoptosis, and Chemotherapy Resistance in Breast Tumor Cells

Lilly Bourguignon, Christina C. Spevak, Gabriel Wong et al. · Journal of Biological Chemistry · 2009 · 313 citations · Full text

Life Sciences, Cell Biology, Oncology +17

A Novel Mechanism for the Inhibition of Hyaluronan Biosynthesis by 4-Methylumbelliferone

Ikuko Kakizaki, Kaoru Kojima, Keiichi Takagaki et al. · Journal of Biological Chemistry · 2004 · 290 citations · Full text

Life Sciences, Biochemistry, Pharmacology +15

4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3

Anne Kultti, Sanna Pasonen‐Seppänen, Marjo Jauhiainen et al. · Experimental Cell Research · 2009 · 287 citations

Life Sciences, Biochemistry, Cell Biology +5

Favorable long-term follow-up results over 6 years for response, survival, and safety with imatinib mesylate therapy in chronic-phase chronic myeloid leukemia after failure of interferon-α treatment

Andreas Hochhaus, Brian Druker, Charles L. Sawyers et al. · Blood · 2007 · 209 citations · Full text

Pharmacy, Hematology, Pharmacotherapy +5