A Novel Mechanism for the Inhibition of Hyaluronan Biosynthesis by 4-Methylumbelliferone

Ikuko Kakizaki, Kaoru Kojima, Keiichi Takagaki, +9

Journal of Biological Chemistry

Chemoprevention StrategyChemical BiologyHa BiosynthesisMedicinal ChemistryBiosynthesis +14

A hyaluronan synthase suppressor, 4‐methylumbelliferone, inhibits liver metastasis of melanoma cells

Shuichi Yoshihara, Atsushi Kon, Daisuke Kudo, +5

FEBS Letters

4-methylumbelliferone, a hyaluronan synthase suppressor, enhances the anticancer activity of gemcitabine in human pancreatic cancer cells

Hideaki Nakazawa, Shuichi Yoshihara, Daisuke Kudo, +5

Cancer Chemotherapy and Pharmacology

Pancreatic CancerMedicineHyaluronan Synthase SuppressorPathologyAnticancer Activity +5

Enzymic Reconstruction of Glycosaminoglycan Oligosaccharide Chains Using the Transglycosylation Reaction of Bovine Testicular Hyaluronidase

Hiromi Saitoh, Keiichi Takagaki, Mitsuo Majima, +5

Journal of Biological Chemistry

Application of 2- Aminopyridine Fluorescence Labeling to Glycosaminoglycans1

Atsushi Kon, Keiichi Takagaki, Hitoshi Kawasaki, +2

The Journal of Biochemistry

Domain Structure of Chondroitin Sulfate E Octasaccharides Binding to Type V Collagen

Keiichi Takagaki, Hidekazu Munakata, Ikuko Kakizaki, +3

Journal of Biological Chemistry

GlycobiologyPolysaccharideMusculoskeletal ResearchBioanalysisMatrix Biology +14

Effect of a hyaluronan synthase suppressor, 4-methylumbelliferone, on B16F-10 melanoma cell adhesion and locomotion

Daisuke Kudo, Atsushi Kon, Shuichi Yoshihara, +4

Biochemical and Biophysical Research Communications

MechanobiologyCell AdhesionHyaluronan Synthase SuppressorCell TraffickingMelanoma +10

Effect of 4‐methylumbelliferone on cell‐free synthesis of hyaluronic acid

T Nakamura, Masaru Funahashi, Keiichi Takagaki, +4

IUBMB Life

Tissue EngineeringBiochemistryHyaluronic AcidHyaluronic Acid SynthaseHuman Tissue +10

Study of hyaluronan synthase inhibitor, 4-methylumbelliferone derivatives on human pancreatic cancer cell (KP1-NL)

Hajime Morohashi, Atsushi Kon, Makoto Nakai, +5

Biochemical and Biophysical Research Communications

Tumor BiologyPancreatic Cancer4-Methylumbelliferone DerivativesMedicineCancer Biology +5

Inhibition of hyaluronan synthesis in <i>Streptococcus equi</i> FM100 by 4‐methylumbelliferone

Ikuko Kakizaki, Keiichi Takagaki, Yasufumi Endo, +9

European Journal of Biochemistry