Lara D. Veeken · 1976 · 26 citations · 0 references
MedicineOrthopaedic SurgeryOrthopedic SurgeryCartilage RepairOrthopedicsRheumatologyCartilage DegenerationCartilage MetabolismJoint DiseaseOsteoarthritisArticular Cartilage LossCartilage DestructionKnee Cartilage Lesions
Indomethacin in pharmacological doses was given to rabbits with papain-induced degenerative arthrosis of the knee. The cartilage lesions healed between the 35th and the 70th day of the experiment. The healing was unaffected by indomethacin. However, autoradiographs showed a significantly reduced 35SO4 uptake in the articular cartilage of the animals receiving the indomethacin in both arthritic and control knees.