ISOLATION AND STRUCTURE OF ASCOFURANONE AND ASCOFRANOL, ANTIBIOTICS WITH HYPOLIPIDEMIC ACTIVITY

Abstract

A new antibiotic with hypolipidemic activity, ascofuranone, C23H29C1O5, and related substance, ascofuranol, C23H31C1O5, were isolated from the filter cake of the fermented broth of Ascochyta viciae LIBERT, an ascochlorin-producing fungus, and their structures were elucidated. They possess 3-substituted-5-chloro-orcylaldehyde moiety with novel sesquiterpenyl side chains.