Induction of T ‘regulatory’ cells by standardized house dust mite immunotherapy: an increase in CD4⁺CD25⁺ interleukin‐10⁺ T cells expressing peripheral tissue trafficking markers

Abstract

Clinically effective subcutaneous immunotherapy with a standardized HDM Dermatophagoides pteronyssinus preparation results in decreased numbers of IL-4+ T cells and expansion of CD4+IL-10+ T cells expressing a peripheral tissue trafficking phenotype. The co-localization of IL-10+ staining to CD4+CD25+ T cells is consistent with the induction of a T regulatory cell population by SIT.