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Biosynthesis of the mitomycin antibiotics from 3-amino-5-hydroxybenzoic acid
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1980
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Medicinal ChemistryBiosynthesisBioorganic ChemistrySpecific IncorporationBiochemistryMitomycin AntibioticsNatural SciencesNatural Product SynthesisBiotransformationNatural Product BiosynthesisMicrobiologyMethylbenzoquinone NucleusSynthetic ChemistryDrug Resistance
The efficient, specific incorporation of isotope from [carboxy-13C]-3-amino-5-hydroxybenzoic acid into the C-6 methyl group of porfiromycin by Streptomyces verticillatus establishes this amino-acid as the biogenetic precursor of the methylbenzoquinone nucleus of the mitomycin antibiotics.