Liebigs Annalen der Chemie · 1989 · 24 citations · 12 references
PharmacyChemistryMedicinal ChemistryDrug DiscoveryMycologyStructure-activity RelationshipsNatural Product Drug DiscoveryRetrosynthetic Analysis
Abstract The chemical behavior of latrunculins A ( 1 ) and B ( 2 ) (Lat A and B) under a variety of reaction conditions is described. The combination of the macrolide, the THP‐lactol, and the 2‐thiazolidinone rings was found to result in interesting unpredicted chemical transformations. The structures of two new Lats, 6,7‐epoxy‐Lat A ( 3 ) and Lat M ( 4 ) isolated from Latrunculia magnifica are discussed.
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Inhibition of actin polymerization by latrunculin A
Martine Coué, Stephen L. Brenner, Ilan Spector et al. · FEBS Letters · 1987 · 840 citations
Latrunculins: Novel Marine Toxins That Disrupt Microfilament Organization in Cultured Cells
Ilan Spector, Nava R. Shochet, Yoel Kashman et al. · Science · 1983 · 759 citations