A Solid‐Phase Route to ¹⁸F‐Labeled Tracers, Exemplified by the Synthesis of [¹⁸F]2‐Fluoro‐2‐deoxy‐<scp>D</scp>‐glucose

Abstract

Scintillating synthesis: 18F-Containing radiopharmaceuticals can be prepared by using [18F]fluoride ions to displace a sulfonate linker and release a radiotracer from a solid support (see scheme; EOM=ethoxymethyl). The method has allowed the synthesis of the widely used imaging agent [18F]fluoro-2-deoxy-D-glucose in good radiochemical yield and with high chemical purity.