Labeled 2‐deoxy‐D‐glucose analogs. ¹⁸F‐labeled 2‐deoxy‐2‐fluoro‐D‐glucose, 2‐deoxy‐2‐fluoro‐D‐mannose and ¹⁴C‐2‐deoxy‐2‐fluoro‐D‐glucose

Abstract

Abstract A convenient method for the synthesis of 18 F‐2‐deoxy‐2‐fluoro‐D‐glucose (4) and 18 F‐2‐deoxy‐2‐fluoro‐D‐mannose (8) by the direct fluorination of 3,4,6‐tri‐0‐acetyl‐D‐glucal with 18 F‐F 2 is described. 14 C‐2‐deoxy‐2‐fluoro‐D‐glucose has been synthesized from 14 C‐3,4,6‐tri‐0‐acetyl‐D‐glucal (from D‐[ 14 c(U)]‐glucose) by fluorination with F 2 (Method 1) and CF 3 OF (Method 2). These labeled analogs of 2‐deoxy‐D‐glucose were required for the study of local cerebral glucose metabolism.