Small · 2010 · 138 citations · 28 references
Dna NanotechnologyDna SequencingEngineeringStrand-displacement ReactionGeneticsDna AnalysisMolecular BiologyGenetic EngineeringDna‐origami Chip PlatformMolecular GeneticsGenome EngineeringNucleic Acid AmplificationGenomicsMedicineCandidate Gene AnalysisDna-origami Chip PlatformBiomolecular EngineeringDna Capture Probes
A DNA-origami chip platform for target-labeling-free single-nucleotide polymorphism (SNP) genotyping is presented. DNA capture probes are anchored on an asymmetric map-shaped DNA-origami chip and a “toehold”-mediated strand-displacement reaction is employed to endow single-base-mismatch differentiation specificity. This design leads to a reliable and potentially universal means for SNP genotyping.
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Folding DNA to create nanoscale shapes and patterns
Paul W. K. Rothemund · Nature · 2006 · 7.3K citations
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Haplotype Determination, Genotype-phenotype Association, Medicine +7
Self-assembly of DNA into nanoscale three-dimensional shapes
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