Application of Multivariate Techniques in Optimization of Spectroanalytical Methods

Abstract

Abstract The present article describes fundamentals and applications of multivariate techniques used for the optimization of analytical procedures and systems involving spectroanalytical methods such as flame atomic absorption spectrometry (FAAS), electrothermal atomic absorption spectrometry (ETAAS), inductively coupled plasma optical emission spectrometry (ICP OES), and inductively coupled plasma mass spectrometry (ICP‐MS), considering the main steps of a chemical analysis. This way, applications of experimental designs in optimization of sampling systems, digestion procedures, preconcentration procedures, instrumental parameters of quantification steps of analytical methods, and robustness tests have been summarized in this work. Keywords: Multivariate techniquesfactorial designcentral composite designDoehlert matrixBox‐Behnken designAASICPspectroanalytical methods