Prognostic significance of loss of O6-methylguanine-DNA methyltransferase expression in supratentorial diffuse low-grade astrocytoma

Inactivation of the DNA-Repair Gene<i>MGMT</i>and the Clinical Response of Gliomas to Alkylating Agents

Manel Esteller, Jesús García‐Foncillas, Esther Andion et al. · New England Journal of Medicine · 2000 · 2.2K citations · Full text

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Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.

Manel Esteller, Stanley R. Hamilton, P C Burger et al. · PubMed · 1999 · 1.3K citations

Medicine, Genetics, Oncology +16

Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial

Martin J. van den Bent, D Afra, Olivier De Witte et al. · The Lancet · 2005 · 1K citations

Medicine, Oncology, Radiation Oncology +17

Prognostic Factors for Survival in Adult Patients With Cerebral Low-Grade Glioma

Francesco Pignatti, Martin J. van den Bent, Desmond Curran et al. · Journal of Clinical Oncology · 2002 · 948 citations

Medicine, Oncology, Surgery +17

DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma.

H. S. Friedman, R E McLendon, Tracy Kerby et al. · Journal of Clinical Oncology · 1998 · 422 citations · Full text

Medicine, Oncology, Pharmacology +17