New Centromere Autoantigens Identified in Systemic Sclerosis Using Centromere Protein Microarrays

Abstract

CENP-P and CENP-Q were identified as novel ACA autoantigens by CENP microarray assays followed by validation of ELISA and Western blotting. Both of them have prognostic utility for interstitial lung disease. CENP-P was associated with renal disease in an ACA-negative cohort.