Correlation of Vasa Vasorum Neovascularization and Plaque Progression in Aortas of Apolipoprotein E ^−/− /Low-Density Lipoprotein ^−/− Double Knockout Mice

Abstract

Our results show that apoE(-/-)/LDL(-/-) double knockout mice develop VV and advanced atheromas along the aorta. Lesion volume was closely associated with amount of neovascularization in advanced atheromas.