Journal of Analytical Toxicology · 1990 · 21 citations · 2 references
PharmacyPharmacologyToxicologyAnalytical ToxicologyPediatric Clinical PharmacologyPharmaceutical ToxicologyGastrointestinal ToxicityPediatric PharmacokineticsPediatric Poisoning ManagementPediatric ToxicologyPoisoning InvestigationToxicological Screening Of PharmaceuticalsDrug Overdose In ChildrenGas Chromatography-mass SpectrometryIngestion PoisoningLaboratory Testing In PoisoningOverdose ToxicityPediatric Poisoning TreatmentPediatric Small Intestine
A 2 1/2-year-old boy was hospitalized following ingestion of an estimated 60 tablets of 200-mg hydroxychloroquine. Upon death from cardiorespiratory arrest, analytes from the stomach, small intestine, liver, and plasma were examined using UV spectroscopy, thin-layer chromatography, and gas chromatography/mass spectrometry. Results indicate modest drug amounts in the stomach and small intestine, but much higher levels in the blood and liver extracts, suggesting that a considerable overdose was consumed.
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R. A. Dalley, D. Hainsworth · Journal of the Forensic Science Society · 1965 · 12 citations