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Publication | Open Access

DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma

DOIFull Paper Access

149

Citations

37

References

2011

Year

Elke Schaeffeler, Claus Hellerbrand, Anne T. Nies, Stefan Winter, Stephan Kruck, Ute Hofmann, Heiko van der Kuip, Ulrich M. Zanger, Hermann Koepsell, Matthias Schwab
Genome Medicine

Abstract

DNA methylation of SLC22A1 is associated with downregulation of SLC22A1 in HCC and might be a new biomarker for HCC diagnosis and prognosis. Moreover, targeting SLC22A1 methylation by demethylating agents may offer a novel strategy for anticancer therapy of HCC.

References

YearCitations

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