Human & Experimental Toxicology · 2013 · 10 citations · 19 references
PharmacyPharmacologyToxicologyDevelopmental ToxicologyEmbryologyReproductive ToxicologyPerinatal ToxicologyPregnancyPregnancy PharmacologyPrenatal ToxicityPrenatal ToxicologyReproductive PharmacologyAntimalarial AgentsAntimalarial Drug CombinationsHistopathological EvaluationMalaria In PregnancyMaternal-fetal ToxicityPlasmodium FalciparumPrenatal Reproductive ToxicityTreatment Of Malaria
Artemisinins combination therapy (ACT) is the first choice therapy for falciparum malaria. Data on the safety of ACTs in pregnancy are limited and controversial and the use is not recommended on the first trimester. To evaluate the effects of isolated and combined artesunate (AS)/mefloquine (MQ) on embryo rats, pregnant rats were treated orally with AS (15 and 40 mg/kg body weight (bwt)/day), MQ (30 and 80 mg/kg bwt/day) and AS/MQ (15/30 and 40/80 mg/kg bwt/day) on days 9-11 post coitum (pc). The dams were euthanized on day 12 pc and gestational and embryos histological parameters were evaluated. Embryolethality and histopathological anomalies were significant when AS was given alone or combined with MQ. Combination of AS and MQ did not enhance their toxicity compared to their separate administrations; on the other side, there was a reduction in the toxic effects of the AS when combined with MQ. Isolated MQ did not induce developmental toxicity.
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The global distribution of clinical episodes of Plasmodium falciparum malaria
Robert W. Snow, Carlos A. Guerra, Abdisalan M. Noor et al. · Nature · 2005 · 2.7K citations · Full text
Veterinary Medicine, Health Sciences, Infectious Diseases +14
Histopathology in fish: proposal for a protocol to assess aquatic pollution
Daniel Bernet, W Meier, Patricia Burkhardt‐Holm et al. · Journal of Fish Diseases · 1999 · 1.3K citations