Preventing antimalarial drug resistance through combinations

Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria.

David S. Peterson, David Walliker, Thomas E. Wellems · Proceedings of the National Academy of Sciences · 1988 · 650 citations · Full text

Point Mutations, Biochemistry, Falciparum Malaria +13

Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum

Simon J. Foote, Jennifer K. Thompson, Alan F. Cowman et al. · Cell · 1989 · 569 citations

Antimicrobial Resistance Gene, Chloroquine-resistant Isolates, Health Sciences +12

Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross

Thomas E. Wellems, Lindsey J. Panton, Ilya Y. Gluzman et al. · Nature · 1990 · 541 citations

Mdr-like Genes, Antimicrobial Resistance Gene, Drug Resistance Analysis +10

Effects of artemisinin derivatives on malaria transmissibility

Ric N. Price, François Nosten, C. Luxemburger et al. · The Lancet · 1996 · 465 citations

Antiparasitic Agent, Medicine, Malaria +3

Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria.

David S. Peterson, Wilbur K. Milhous, Thomas E. Wellems · Proceedings of the National Academy of Sciences · 1990 · 419 citations · Full text

Bioorganic Chemistry, Antiparasitic Agent, Malaria +19