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Quasispecies of TT Virus (TTV) with Sequence Divergence in Hypervariable Regions of the Capsid Protein in Chronic TTV Infection

Tsutomu Nishizawa, Hiroaki Okamoto, Fumio Tsuda, Tatsuya Aikawa, Yoshiki Sugai, Keiko Konishi, Yoshihiro Akahane, Masato Ukita, Takeshi Tanaka, Yuzo Miyakawa,

Journal of Virology · 1999 · 94 citations · 28 references

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Abstract

Three hypervariable regions were identified in a central portion of open reading frame 1 of TT virus DNA, which codes for a putative capsid protein of 770 amino acids. TT virus circulates as quasispecies, with many amino acid substitutions in hypervariable regions, to evade immune surveillance of the hosts and to establish a persistent infection.

References

28

Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate

Jesse Summers, William S. Mason · Cell · 1982 · 1.4K citations

, , +13

A Novel DNA Virus (TTV) Associated with Elevated Transaminase Levels in Posttransfusion Hepatitis of Unknown Etiology

Tsutomu Nishizawa, Hiroaki Okamoto, Keiko Konishi et al. · Biochemical and Biophysical Research Communications · 1997 · 1.2K citations

, , +17

Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature of HCV genome distribution

Marı́a Martell, Juan Ignacio Esteban, Josep Quer et al. · Journal of Virology · 1992 · 931 citations · Full text

, , +16

Temporal fluctuations in HIV quasispecies in vivo are not reflected by sequential HIV isolations

Andreas Meyerhans, Rémi Cheynier, Jan Albert et al. · Cell · 1989 · 656 citations

, , +12

Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins

Amy J. Weiner, Matthew J. Brauer, Jody Rosenblatt et al. · Virology · 1991 · 605 citations

, , +16