Publication | Open Access

Bioisosteric replacement of an acylureido moiety attached to an indolin-2-one scaffold with a malonamido or a 2/4-pyridinoylamido moiety produces a selectively potent Aurora-B inhibitor

Bioisosteric ReplacementCombinatorial ChemistryMedicinal ChemistryBioorganic ChemistryBiochemistryNatural SciencesMedicineIndolin-2-one ScaffoldChemical BiologyPharmacologyPharmaceutical ChemistryInhibitory ActivityAcylureido MoietyDrug Discovery