Concepedia

Acrosomal biogenesis in human globozoospermia: immunocytochemical, ultrastructural and proteomic studies

C. Alvarez Sedó, Vanesa Y. Rawe, H Chemes

Human Reproduction · 2012 · 45 citations · 44 references

DOIFull text

Open access

Abstract

The alterations observed during early acrosome biogenesis in globozoospermia are due to anomalous development of Golgi-derived proacrosomic vesicles, failure of PT proteins to properly associate with the nuclear surface and significant deficiencies in specific PT components that are necessary for proper acrosome formation, implantation and expansion over the spermatid nucleus.

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