John Parrington

PLCζ: a sperm-specific trigger of Ca2+ oscillations in eggs and embryo development

Christopher M. Saunders, Mark G. Larman, John Parrington et al. · Development · 2002 · 995 citations

NAADP mobilizes calcium from acidic organelles through two-pore channels

Peter Calcraft, Margarida Ruas, Zui Pan et al. · Nature · 2009 · 740 citations · Full text

Molecular Physiology, Signal Transduction, Medicine +7

Calcium oscillations in mammalian eggs triggered by a soluble sperm protein

John Parrington, Karl Swann, Valery I. Shevchenko et al. · Nature · 1996 · 378 citations

Spermatogenesis, Biology, Infertility +10

Human sperm devoid of PLC, zeta 1 fail to induce Ca2+ release and are unable to initiate the first step of embryo development

Sook‐Young Yoon, Teru Jellerette, Ana M. Salicioni et al. · Journal of Clinical Investigation · 2008 · 321 citations · Full text

Reduced amounts and abnormal forms of phospholipase C zeta (PLC ) in spermatozoa from infertile men

Elke Heytens, John Parrington, Kevin Coward et al. · Human Reproduction · 2009 · 290 citations · Full text