SecYEG assembles into a tetramer to form the active protein translocation channel

The binding cascade of SecB to SecA to SecYE mediates preprotein targeting to the E. coli plasma membrane

F. Ulrich Hartl, Stewart H. Lecker, Joseph P. Hendrick et al. · Cell · 1990 · 561 citations

Protein Secretion, E. Coli, Signal Transduction +10

The ATPase activity of secA is regulated by acidic phospholipids, secY, and the leader and mature domains of precursor proteins

Roland Lill, William Dowhan, William Wickner · Cell · 1990 · 551 citations

Atpase Activity, Proteinlipid Interaction, Protein Secretion +10

SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion

Anastassios Economou, William Wickner · Cell · 1994 · 524 citations

Protein Secretion, Molecular Physiology, Biochemistry +12

The purified E. coli integral membrane protein is sufficient for reconstitution of SecA-dependent precursor protein translocation

Lorna Brundage, Joseph P. Hendrick, Arnold J. M. Driessen et al. · Cell · 1990 · 515 citations

Protein Secretion, Protein Expression, Natural Sciences +7

ΔμH+ and ATP function at different steps of the catalytic cycle of preprotein translocase

Arnold J. M. Driessen, F. Ulrich Hartl, William Wickner · Cell · 1991 · 461 citations

Cellular Enzymology, Biochemistry, Natural Sciences +6