Journal of Microelectromechanical Systems · 2000 · 63 citations · 20 references
EngineeringBioengineeringBiomedical EngineeringComputational Fluid DynamicsFluid DynamicsTransport PhenomenaBiofluid MechanicsMicrofluidic DevicesMicrofluidic SystemsMicrofluidic TransportMicrofluidicsOsmosisBiological Sample AnalysisElectroosmotic FlowLaplace EquationNavier-stokes SolversNumerical SimulationOsmotic TransportPoisson-boltzmann EquationReynolds Number
An emerging technology in the area of microsystems is micro-total analysis systems (/spl mu/TAS) for biological sample analysis. We have simulated electro-osmosis-a common transport mechanism within these devices-by developing meshless techniques. Numerical simulation of electro-osmotic transport requires the solution of the Laplace equation, the Poisson-Boltzmann equation and the incompressible Stokes or Navier-Stokes equations. We describe the development and implementation of meshless techniques for all the governing equations. In particular we introduce a stabilized Stokes solver for very-low Reynolds number flows and a multistep Navier-Stokes solver for a wide range of Reynolds number flows. We have analyzed electro-osmotic transport in three geometries typically encountered in biological devices: a straight channel, a cross-shaped intersection, and a T-shaped intersection.
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A. Brooks, Thomas J.R. Hughes · Computer Methods in Applied Mechanics and Engineering · 1982 · 5.3K citations
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Alexandre J. Chorin · Mathematics of Computation · 1968 · 5.3K citations
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Computing, Computational Engineering, Mechanical Engineering +12